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Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Lutein (Marigold Petal Extract) (Tagetes erecta)
20 mg
†
Zeaxanthin (Marigold Petal Extract) (Tagetes erecta)
4 mg
†
Top Medical Research Studies
8
We explored the relationship between serum levels of carotenoids, like lutein, and cardiovascular-kidney-metabolic syndrome in over 1,600 U.S. adults. Through extensive analysis, we found that higher lutein levels corresponded with a lower likelihood of advanced CKM syndrome. Other carotenoids also showed similar protective effects, but β-cryptoxanthin did not demonstrate any significant benefit. This suggests that increasing intake of carotenoids, especially lutein, may be a smart choice for heart health.
Read More
8
We aimed to investigate how levels of certain carotenoids impact mortality rates in adults with metabolic dysfunction-associated fatty liver disease (MAFLD). Our analysis involved over 3,000 participants and focused on deaths from all causes, including cardiovascular issues.
Interestingly, higher levels of lutein and other carotenoids correlated with a lower risk of death. Specifically, those with the highest lutein levels were 38% less likely to die from cardiovascular disease compared to those with the lowest levels. However, it's important to note that while the correlation exists, we cannot definitively claim that lutein directly prevents heart disease based on this study alone.
Interestingly, higher levels of lutein and other carotenoids correlated with a lower risk of death. Specifically, those with the highest lutein levels were 38% less likely to die from cardiovascular disease compared to those with the lowest levels. However, it's important to note that while the correlation exists, we cannot definitively claim that lutein directly prevents heart disease based on this study alone.
Read More
8
Supplementation reduces inflammation markers
In our double-blind, placebo-controlled study, we assessed the effects of lutein, zeaxanthin, and meso-zeaxanthin on cardiovascular inflammation and oxidative processes. Participants received either the active supplement or a placebo for six months.
We found significant reductions in key inflammatory markers and oxidized LDL in those taking the supplement. These results suggest that lutein and its companions may help combat inflammation, potentially contributing to healthier cardiovascular systems by supporting lower levels of harmful lipid oxidation.
We found significant reductions in key inflammatory markers and oxidized LDL in those taking the supplement. These results suggest that lutein and its companions may help combat inflammation, potentially contributing to healthier cardiovascular systems by supporting lower levels of harmful lipid oxidation.
Read More
Most Useful Reviews
8
Cardiovascular system support
This product positively influences the cardiovascular system, lowering the risk of cardiovascular disease, including atherosclerosis and strokes. Additionally, adequate lutein intake helps prevent retinal detachment and cataracts associated with ageing.
Read More
8
Eye disease prevention
3 people found this helpful
This product optimally balances lutein and zeaxanthin at a 5:1 ratio, as evidenced by the AREDS2 clinical trial. It is effective in preventing conditions such as cataracts and visual disturbances.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.3
- All Researches
9
We explored the potential of lutein, a powerful antioxidant, in treating myocardial ischemia-reperfusion injury. To enhance its effectiveness, a novel delivery system named lutein@DTPP was developed, allowing for targeted administration directly to heart tissues.
Our findings showed that this method improved mitochondrial function in heart cells, crucial for reducing damage and preventing cell death. However, while lutein demonstrated benefits in this context, it's important to note that the study primarily focused on a specific injury model, and broader effects on cardiovascular disease might still require more investigation.
Our findings showed that this method improved mitochondrial function in heart cells, crucial for reducing damage and preventing cell death. However, while lutein demonstrated benefits in this context, it's important to note that the study primarily focused on a specific injury model, and broader effects on cardiovascular disease might still require more investigation.
Read More
8
We explored the relationship between serum levels of carotenoids, like lutein, and cardiovascular-kidney-metabolic syndrome in over 1,600 U.S. adults. Through extensive analysis, we found that higher lutein levels corresponded with a lower likelihood of advanced CKM syndrome. Other carotenoids also showed similar protective effects, but β-cryptoxanthin did not demonstrate any significant benefit. This suggests that increasing intake of carotenoids, especially lutein, may be a smart choice for heart health.
Read More
8
We aimed to investigate how levels of certain carotenoids impact mortality rates in adults with metabolic dysfunction-associated fatty liver disease (MAFLD). Our analysis involved over 3,000 participants and focused on deaths from all causes, including cardiovascular issues.
Interestingly, higher levels of lutein and other carotenoids correlated with a lower risk of death. Specifically, those with the highest lutein levels were 38% less likely to die from cardiovascular disease compared to those with the lowest levels. However, it's important to note that while the correlation exists, we cannot definitively claim that lutein directly prevents heart disease based on this study alone.
Interestingly, higher levels of lutein and other carotenoids correlated with a lower risk of death. Specifically, those with the highest lutein levels were 38% less likely to die from cardiovascular disease compared to those with the lowest levels. However, it's important to note that while the correlation exists, we cannot definitively claim that lutein directly prevents heart disease based on this study alone.
Read More
8
Supplementation reduces inflammation markers
In our double-blind, placebo-controlled study, we assessed the effects of lutein, zeaxanthin, and meso-zeaxanthin on cardiovascular inflammation and oxidative processes. Participants received either the active supplement or a placebo for six months.
We found significant reductions in key inflammatory markers and oxidized LDL in those taking the supplement. These results suggest that lutein and its companions may help combat inflammation, potentially contributing to healthier cardiovascular systems by supporting lower levels of harmful lipid oxidation.
We found significant reductions in key inflammatory markers and oxidized LDL in those taking the supplement. These results suggest that lutein and its companions may help combat inflammation, potentially contributing to healthier cardiovascular systems by supporting lower levels of harmful lipid oxidation.
Read More
8
Our analysis focused on how carotenoid intake relates to abdominal aortic calcification (AAC), a crucial indicator of cardiovascular risk. In a study with 2,889 participants, we found that increased consumption of carotenoids—particularly lutein and zeaxanthin—was linked to a reduced risk of severe AAC.
Results showed that higher intakes of various carotenoids, including lutein, significantly lowered the odds of AAC, emphasizing the potential heart health benefits of these nutrients. This suggests that including more carotenoid-rich foods in our diet might be beneficial for our cardiovascular health.
Results showed that higher intakes of various carotenoids, including lutein, significantly lowered the odds of AAC, emphasizing the potential heart health benefits of these nutrients. This suggests that including more carotenoid-rich foods in our diet might be beneficial for our cardiovascular health.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8
Cardiovascular system support
This product positively influences the cardiovascular system, lowering the risk of cardiovascular disease, including atherosclerosis and strokes. Additionally, adequate lutein intake helps prevent retinal detachment and cataracts associated with ageing.
Read More
8
Eye disease prevention
3 people found this helpful
This product optimally balances lutein and zeaxanthin at a 5:1 ratio, as evidenced by the AREDS2 clinical trial. It is effective in preventing conditions such as cataracts and visual disturbances.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Sun L, He Z, Li Y, Huo Z, Liu L. The relationship between nutrient intake, lifestyle, and non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus: Results from the National Health and Nutrition Examination Surveys 2007-2018. Clin Nutr ESPEN. 2025;66:446. 10.1016/j.clnesp.2025.02.008
- Li C, Liang Y, Lu Q, Lin Y, Wen S, et al. Protective effect of serum carotenoids on mortality among metabolic syndrome patients: attenuated by lipid-lowering drugs. Nutr J. 2025;24:27. 10.1186/s12937-025-01092-x
- Chen M, Cai S, Jia Q, Suo Y, Tang Y, et al. Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular-Kidney-Metabolic Syndrome Among the General Adult Population. J Diabetes. 2025;17:e70046. 10.1111/1753-0407.70046
- Shi P, Sha Y, Wang X, Yang T, Wu J, et al. Targeted Delivery and ROS-Responsive Release of Lutein Nanoassemblies Inhibit Myocardial Ischemia-Reperfusion Injury by Improving Mitochondrial Function. Int J Nanomedicine. 2024;19:11973. 10.2147/IJN.S488532
- Lin B, Liu Z, Li D, Zhang T, Yu C. Associations of serum carotenoids with all-cause and cardiovascular mortality in adults with MAFLD. Nutr Metab Cardiovasc Dis. 2024;34:2315. 10.1016/j.numecd.2024.06.001
- Stringham NT, Green M, Roche W, Prado-Cabrero A, Mulcahy R, et al. Lutein, zeaxanthin, and meso-zeaxanthin supplementation attenuates inflammatory cytokines and markers of oxidative cardiovascular processes in humans. Nutr Metab Cardiovasc Dis. 2024;34:1976. 10.1016/j.numecd.2024.05.009
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. 10.2147/CIA.S461821
- Chen W, Li Y, Li M, Li H, Chen C, et al. Association between dietary carotenoid intakes and abdominal aortic calcification in adults: National Health and Nutrition Examination Survey 2013-2014. J Health Popul Nutr. 2024;43:20. 10.1186/s41043-024-00511-9
- Kolar L, Šušnjara P, Stupin M, Stupin A, Jukić I, et al. Enhanced Microvascular Adaptation to Acute Physical Stress and Reduced Oxidative Stress in Male Athletes Who Consumed Chicken Eggs Enriched with n-3 Polyunsaturated Fatty Acids and Antioxidants-Randomized Clinical Trial. Life (Basel). 2023;13. 10.3390/life13112140
- Ba W, Xu W, Deng Z, Zhang B, Zheng L, et al. The Antioxidant and Anti-Inflammatory Effects of the Main Carotenoids from Tomatoes via Nrf2 and NF-κB Signaling Pathways. Nutrients. 2023;15. 10.3390/nu15214652
- Wang M, Tang R, Zhou R, Qian Y, Di D. The protective effect of serum carotenoids on cardiovascular disease: a cross-sectional study from the general US adult population. Front Nutr. 2023;10:1154239. 10.3389/fnut.2023.1154239
- Šušnjara P, Mihaljević Z, Stupin A, Kolobarić N, Matić A, et al. Consumption of Nutritionally Enriched Hen Eggs Enhances Endothelium-Dependent Vasodilation via Cyclooxygenase Metabolites in Healthy Young People-A Randomized Study. Nutrients. 2023;15. 10.3390/nu15071599
- Zhu X, Cheang I, Tang Y, Shi M, Zhu Q, et al. Associations of Serum Carotenoids With Risk of All-Cause and Cardiovascular Mortality in Hypertensive Adults. J Am Heart Assoc. 2023;12:e027568. 10.1161/JAHA.122.027568
